This advanced science school will address the main challenges related to Structural Safety and Infrastructure Resilience in a climate change context, as well as the tools required to address them. Climate change is already producing more frequent and more intense weather-related events, which have an impact on structural loads and their mean return rates. Increasing infrastructure resilience in this context is fundamental to reduce the impact of climate change on social wellbeing. Climate change is also pressing the production of cement with reduced CO2 emissions: yet, the durability of reinforced concrete made with these cements is still unknown. A potential reduction in the expected lifetime of such structures may completely offset the environmental gains in using reduced clinker cement. The compounding effect of more intense storms with unknown lifetime of reinforced concrete structures may be disastrous to the built environment. The above issues can be addressed by Structural Reliability (SR) methods, Performance Based Engineering (PBE) and risk-based optimization. SR methods have been used by the profession to quantify the uncertainties in loads, material strengths and engineering models, leading to objective measures of structural safety. PBE is a modern approach to address the uncertainty in stochastic process loads such as earthquakes, tornados, hurricanes and waves. Risk-based optimization addresses the compromise solutions between structural safety and costs/emissions, considering lifecycle costs such as construction, inspection and maintenance, as well as expected costs of failure.